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sc-219364.pdf

    1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING

    Product identifier Product Name Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide Product Code SC-219364 Recommended use of the chemical and restrictions on use For research use only. Not intended for diagnostic or therapeutic use.

    2. HAZARDS IDENTIFICATION

    This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification Acute toxicity - Oral Category 3 Label elements Signal word Danger Hazard statements Toxic if swallowed Symbols/Pictograms Precautionary Statements - Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Precautionary Statements - Response IF exposed or concerned: Get medical advice/attention IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Precautionary Statements - Storage Store locked up Precautionary Statements - Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Hazards not otherwise classified (HNOC) Not applicable Other Information

    3. COMPOSITION/INFORMATION ON INGREDIENTS

    CAS No 1040920-61-3 Molecular Weight 320.34 Formula C16 H20 N2O5

    4. FIRST AID MEASURES

    First Aid Measures General advice Consult a physician if necessary. Remove to fresh air. Eye contact Wash with plenty of water. Skin Contact Wash skin with soap and water. Inhalation Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration Ingestion Never give anything by mouth to an unconscious person. Clean mouth with water. Most important symptoms and effects, both acute and delayed Symptoms No information available. Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically.

    5. FIRE-FIGHTING MEASURES

    Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Unsuitable Extinguishing Media No information available. Specific hazards arising from the chemical Specific hazards arising from the chemical No information available. Hazardous combustion products Carbon oxides. Nitrogen oxides (NOx). Explosion data Sensitivity to Mechanical Impact No information available. Sensitivity to Static Discharge No information available. Protective equipment and precautions for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

    6. ACCIDENTAL RELEASE MEASURES

    Personal precautions Ensure adequate ventilation, especially in confined areas. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Use personal protective equipment as required. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically, placing in appropriate containers for disposal. Avoid creating dust. Clean contaminated surface thoroughly.

    7. HANDLING AND STORAGE

    Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Storage Conditions Protect from moisture. Store at -20 °C. Incompatible materials None known based on information supplied.

    8. EXPOSURE CONTROLS/PERSONAL PROTECTION

    Control parameters Exposure Guidelines This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Appropriate engineering controls Showers Eyewash stations Ventilation systems Individual protection measures, such as personal protective equipment Eye/face protection Wear safety glasses with side shields (or goggles). Skin and Body Protection Wear protective gloves and protective clothing. Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations. General Hygiene Considerations Handle in accordance with good industrial hygiene and safety practice.

    9. PHYSICAL AND CHEMICAL PROPERTIES

    Physical State Solid Appearance No information available Odor No information available Property Values pH No information available Melting point/freezing point 164 °C Boiling point No information available Flash point No information available Liquid Density No information available Evaporation rate No information available Upper flammability limits Explosive properties No information available Oxidizing properties No information available

    10. STABILITY AND REACTIVITY

    Chemical stability Stable under recommended storage conditions. Possibility of Hazardous Reactions None under normal processing. Hazardous polymerization No information available. Conditions to avoid Exposure to air or moisture over prolonged periods. Incompatible materials Strong oxidizing agents. Hazardous Decomposition Products Carbon oxides. Nitrogen oxides (NOx).

    11. TOXICOLOGICAL INFORMATION

    Information on likely routes of exposure Inhalation No data available. Eye contact No data available. Skin Contact No data available. Ingestion No data available. Information on toxicological effects Symptoms No information available. Delayed and immediate effects as well as chronic effects from short and long-term exposure Chronic Toxicity No information available. Numerical measures of toxicity - Product Information Unknown acute toxicity No information available The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 100 mg/kg

    12. ECOLOGICAL INFORMATION

    Ecotoxicity May cause long lasting harmful effects to aquatic life 100% of the mixture consists of components(s) of unknown hazards to the aquatic environment. Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available. Lower flammability limit No information available Vapor pressure No information available Vapor density No information available Specific gravity No information available Water solubility No information available Solubility in other solvents No information available Partition coefficient No information available Autoignition temperature No information available Decomposition temperature 164 ° C Kinematic viscosity No information available Reactivity Not applicable

    13. DISPOSAL CONSIDERATIONS

    Disposal of wastes Disposal should be in accordance with applicable regional, national and local laws and regulations. Contaminated packaging Do not reuse container.

    14. TRANSPORT INFORMATION

    DOT UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compounds, solid, n.o.s. Description UN1655, Nicotine compounds, solid, n.o.s., 6.1, III Emergency Response Guide Number 151 IMDG UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compound, solid, n.o.s. Description UN1655, Nicotine compound, solid, n.o.s., 6.1, III Special Provisions 223, 274, 43 EmS-No F-A, S-A IATA UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compound, solid, n.o.s. Description UN1655, Nicotine compound, solid, n.o.s., 6.1, III ERG Code 6L

    15. REGULATORY INFORMATION

    International Inventories All of the components in the product are on the following Inventory lists No information available US Federal Regulations SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute health hazard Yes Chronic Health Hazard No Fire hazard No Sudden release of pressure hazard No Reactive hazard No CWA (Clean Water Act) This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42). US State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. U.S. State Right-to-Know Regulations This product does not contain any substances regulated by state right-to-know regulations

    16. OTHER INFORMATION

    Revision note No information available Disclaimer The information provided in this Material Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.

    Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide******

    1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING

    Product identifier Product Name Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide Product Code SC-219364 Recommended use of the chemical and restrictions on use For research use only. Not intended for diagnostic or therapeutic use.

    2. HAZARDS IDENTIFICATION

    This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification Acute toxicity - Oral Category 3 Label elements Signal word Danger Hazard statements Toxic if swallowed Symbols/Pictograms Precautionary Statements - Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Precautionary Statements - Response IF exposed or concerned: Get medical advice/attention IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Precautionary Statements - Storage Store locked up Precautionary Statements - Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Hazards not otherwise classified (HNOC) Not applicable Other Information

    3. COMPOSITION/INFORMATION ON INGREDIENTS

    CAS No 1040920-61-3 Molecular Weight 320.34 Formula C16 H20 N2O5

    4. FIRST AID MEASURES

    First Aid Measures General advice Consult a physician if necessary. Remove to fresh air. Eye contact Wash with plenty of water. Skin Contact Wash skin with soap and water. Inhalation Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration Ingestion Never give anything by mouth to an unconscious person. Clean mouth with water. Most important symptoms and effects, both acute and delayed Symptoms No information available. Indication of any immediate medical attention and special treatment needed Note to physicians Treat symptomatically.

    5. FIRE-FIGHTING MEASURES

    Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Unsuitable Extinguishing Media No information available. Specific hazards arising from the chemical Specific hazards arising from the chemical No information available. Hazardous combustion products Carbon oxides. Nitrogen oxides (NOx). Explosion data Sensitivity to Mechanical Impact No information available. Sensitivity to Static Discharge No information available. Protective equipment and precautions for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

    6. ACCIDENTAL RELEASE MEASURES

    Personal precautions Ensure adequate ventilation, especially in confined areas. Environmental precautions See Section 12 for additional Ecological Information. Methods and material for containment and cleaning up Methods for containment Prevent further leakage or spillage if safe to do so. Methods for cleaning up Use personal protective equipment as required. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically, placing in appropriate containers for disposal. Avoid creating dust. Clean contaminated surface thoroughly.

    7. HANDLING AND STORAGE

    Precautions for safe handling Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Conditions for safe storage, including any incompatibilities Storage Conditions Protect from moisture. Store at -20 °C. Incompatible materials None known based on information supplied.

    8. EXPOSURE CONTROLS/PERSONAL PROTECTION

    Control parameters Exposure Guidelines This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Appropriate engineering controls Showers Eyewash stations Ventilation systems Individual protection measures, such as personal protective equipment Eye/face protection Wear safety glasses with side shields (or goggles). Skin and Body Protection Wear protective gloves and protective clothing. Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations. General Hygiene Considerations Handle in accordance with good industrial hygiene and safety practice.

    9. PHYSICAL AND CHEMICAL PROPERTIES

    Physical State Solid Appearance No information available Odor No information available Property Values pH No information available Melting point/freezing point 164 °C Boiling point No information available Flash point No information available Liquid Density No information available Evaporation rate No information available Upper flammability limits Explosive properties No information available Oxidizing properties No information available

    10. STABILITY AND REACTIVITY

    Chemical stability Stable under recommended storage conditions. Possibility of Hazardous Reactions None under normal processing. Hazardous polymerization No information available. Conditions to avoid Exposure to air or moisture over prolonged periods. Incompatible materials Strong oxidizing agents. Hazardous Decomposition Products Carbon oxides. Nitrogen oxides (NOx).

    11. TOXICOLOGICAL INFORMATION

    Information on likely routes of exposure Inhalation No data available. Eye contact No data available. Skin Contact No data available. Ingestion No data available. Information on toxicological effects Symptoms No information available. Delayed and immediate effects as well as chronic effects from short and long-term exposure Chronic Toxicity No information available. Numerical measures of toxicity - Product Information Unknown acute toxicity No information available The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 100 mg/kg

    12. ECOLOGICAL INFORMATION

    Ecotoxicity May cause long lasting harmful effects to aquatic life 100% of the mixture consists of components(s) of unknown hazards to the aquatic environment. Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available. Lower flammability limit No information available Vapor pressure No information available Vapor density No information available Specific gravity No information available Water solubility No information available Solubility in other solvents No information available Partition coefficient No information available Autoignition temperature No information available Decomposition temperature 164 ° C Kinematic viscosity No information available Reactivity Not applicable

    13. DISPOSAL CONSIDERATIONS

    Disposal of wastes Disposal should be in accordance with applicable regional, national and local laws and regulations. Contaminated packaging Do not reuse container.

    14. TRANSPORT INFORMATION

    DOT UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compounds, solid, n.o.s. Description UN1655, Nicotine compounds, solid, n.o.s., 6.1, III Emergency Response Guide Number 151 IMDG UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compound, solid, n.o.s. Description UN1655, Nicotine compound, solid, n.o.s., 6.1, III Special Provisions 223, 274, 43 EmS-No F-A, S-A IATA UN/ID no UN1655 Hazard Class 6.1 Packing Group III Proper shipping name Nicotine compound, solid, n.o.s. Description UN1655, Nicotine compound, solid, n.o.s., 6.1, III ERG Code 6L

    15. REGULATORY INFORMATION

    International Inventories All of the components in the product are on the following Inventory lists No information available US Federal Regulations SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute health hazard Yes Chronic Health Hazard No Fire hazard No Sudden release of pressure hazard No Reactive hazard No CWA (Clean Water Act) This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42). US State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. U.S. State Right-to-Know Regulations This product does not contain any substances regulated by state right-to-know regulations

    16. OTHER INFORMATION

    Revision note No information available Disclaimer The information provided in this Material Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.

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