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sds-FN26205.pdf

1 Identification of the substance

1.1 Product identifier Identification of the substance Nicotine salicylate Additional identification Eudermol Cataloge Number FN26205 REACH No. A registration number is not available for this substance as the substance or its uses are exempted from registration or the annual tonnage does not require a registration.

1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses other biochemicals Restriction on use not for food or drug use, for laboratory use only

1.3 Details of the suppller of the safty data sheet Company Carbosynth Ltd 8&9 Old Station Business Park COMPTON RG20 6NE

1.4 Emergency telephone number Phone 24hr/7days: +44 118 338 8269

2 Hazards identification

2.1 Classification of the substance or mixturet Physical Hazards not classified Health Hazards serious irritation (Category 2) Eye irritation (Category 2), H319 acute toxicity (Category 2) Specific target organ toxicity, single exposure (Category 3), H335 Enviromental Hazards Chronic aquatic toxicity (Category 2), H411

2.2 Label elements Regulatory List EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP) Symbol GHS06 skull and crossbones Pictogram GHS07 exclamation mark Pictogram GHS09 environmental hazards Pictogram Signal Word Danger Hazard Statement H300 Fatal if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H411 Toxic to aquatic life with long lasting effects. H335 May cause respiratory irritation. Precautionary Statement P264 Wash thoroughly after handling. P270 Do no eat, drink or smoke when using this product. P301 IF SWALLOWED: P310 Immediately call a POISON CENTER or doctor/physician. P330 Rinse mouth. P501 Dispose of contents / container in accordance with local / regional / national /international regulations. P302+P352 IF ON SKIN: Wash with plenty of soap and water. P304+P340 IF INHALED: Remove casualty to fresh air and keepat rest in a position comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Remove contact lenses, if possible. P403+P233 Store in a well-ventilated place. Keep containertightly closed. P273 Avoid release to the environment. P391 Collect spillage.

2.3 Other hazards Caution! To the best of our knowledge the toxicological properties of this material have not been thoroughly investigated.

3 Composition/information on ingredients

Substance related information Nicotine salicylate Substance name Eudermol Synonyms [29790-52-1] Cas No. Formula C17 H20 N 2 O3

4 First aid measures

4.1 Description of first aid measures First Aid: Eye Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist. First Aid: Skin Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician. First Aid: Ingestion Wash out mouth with water provided person is conscious. Call a physician.

4.2 Most important symptoms and effects, both acute and delayed Hints for Physician: Symptoms See Section 11 for additonal information on health hazards

4.3 Indication of any immediate medical attention and special treatment needed First Aid: Inhalation Remove casualty to fresh air and keep warm and at rest. If breathing is irregular or stopped, administer artificial respiration. Call a physician. Hints for Physician: Treatment Treat symptomatically.

5 Firefighting measures

5.1 Extinguishing Media Suitable foam, dry extinguishing powder, carbon dioxide (CO2), water spray jet

5.2 Special hazards arising from the substance or mixturet Wear a self-contained breathing apparatus and chemical protective clothing. Hazards During Fire-Fighting toxic fumes

5.3 Fire-Fighting/Further Advice Do not inhale explosion and combustion gases. Collect contaminated fire extinguishing water separately. This must not be discharged into drains. Move undamaged containers from immediate hazard area if it can be done safely.

6 Accidental release measures

6.1 Personal Precautions, potective equipment and emergency procedures Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

6.2 Environmental Precautions Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

6.3 Methods and material for containment and cleaning up not available

6.4 Further Accidental Release Measures Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.

7 Handling and storage

7.1 Precautions for safe handling Handling advice Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.

7.2 Conditions for safe storage, including any incompatibilities Storage temperature store at 2°C - 8°C Storage Requirements Keep away from incompatible substances. Keep container tightly closed when not in use.

8 Exposure controles/personal protection

8.1 Exposure limit values Does not contain any substances with occupational exposure limits.

8.2 Exposure controles Industrial Hygiene Mechanical exhaust required. Safety shower and eye shower.

8.3 Personal Protective Equipment Respiratory Protection Wear NIOSH/MSHA or European Standard EN 149 approved respirator. Hand Protection Wear compatible chemical-resistant gloves to prevent skin exposure. Eye Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA. Body Protection Wear compatible chemical-resistant gloves and clothing to prevent skin exposure. Advice on Safe Handling Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.

9 Physical and chemical properties

9.1 Information on basic Physical and chemical color properties Form powder Phase Transition Solid/Liquid 112.00 °C

9.2 Other information Molar Mass 300.35 g/mol

10 Stability and reactivity

10.1 Reactivity No Data Available

10.2 Chemical stability No Data Available

10.3 Possibility of hazardous reaction No Data Available

10.4 Conditions to Avoid (SDS) incompatible materials

10.5 Incompatible materials strong oxidizers

10.6 Hazardous decomposition products nitrogen oxides (NOx), carbon dioxide (CO2), carbon monoxide

11 Toxicological information

11.1 Information on toxicological effects Other Relevant Toxicity Information We are not aware of any toxicology data.

12 Ecological Information

12.1 Toxicity Acute toxicity versus Fishing Test Type Species Method Exposure Time Value in standard unit mg/l No data available No data available No data available No data available No data available Acute toxicity in aquatic plants Test Type Species Method Exposure Time Value in standard unit mg/l No data available No data available No data available No data available No data available Acute toxicity versus Daphnia and others aquatic invertebrates Test Type Species Method Exposure Time Value in standard unit mg/l No data available No data available No data available No data available No data available

12.2 Persistence and degradablity Remarks : no data available

12.3 Bioaccumulative potential Remarks : no data available

12.4 Mobility in soil no data available

12.5 Results of PBT and vPvB assessment no data available

12.6 Other adverse effects Memo : Toxic to aquatic life.

13 Disposal considerations

Advice on Disposal and Packaging Advice on Disposal Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and Exhaust air. Dispose of waste according to laws applicable. Advice on Packaging not available

14 Transport information

Road Transport(ADR/GGVS) Air Transport(IATA) 14.1 UN number 1657 1657 14.2 UN proper shipping name NICOTINE SALICYLATE NICOTINE SALICYLATE 14.3 Transport hazard class(es) 6.1 6.1 14.4 Packing group II II 14.5 Enviromental hazard class (es) Hazards identified Hazards identified 14.6 Special precautions for user Transport in bulk or in tanks: see long text. Not applicable 14.7 Transport in bulk according to Annex 11 of MARPOL and the IBC code Not applicable Not applicable

15 Other regulations

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixturet Component REACH (1907/2006) -Annex XIV - Substances Subject to Authorization REACH (1907/2006) -Annex XVII - Restrictions on Certain Dangerous Substances REACH Regulation (EC 1907/2006) article 59 -Candidate List of Substances of Very High Concern (SVHC) Nicotine salicylate ----- Regulatory List EINECS, INSQ, PICCS, TCSI

15.2 Chemical safty assessment No chemical safety assessment has been carried out.