EUR
en
1.1 Product Identifier / Product Name REF 740396 Product Name Liquid Proteinase K (5 mL) 1 x 5 mL Liquid Proteinase K UFI: TTWV-43C9-R202-NTGN
1.2 Relevant identified Uses of the Substance or Mixture and Uses advised against Relevant identified uses Product for analytical use. Exposure Scenario Classification according REACh, RIP 3.2 Codes: SU 0-2, PC 21, PROC 15, AC 0The exposure scenario is integrated into sections 1-16. Uses advised against not described
1.3 Details of the Supplier and of the Safety Data Sheet Manufactured by: MACHEREY-NAGEL GmbH & Co. KG Valencienner Str. 11, 52355 Düren, Germany Phone: +49 2421 969 0 E-mail: sds@mn-net.com
1.4 Emergency Telephone Number Outside Germany (DE): Call your regional Poisons Information Service or call local Life Saving Service. USA: American Association Of Poison Control Centers Rockville, MD 20857. tel. 1-800-222-1222
2.0 Classification of the complete Product GHS08 Signal Word DANGER Hazard Identification Hazard Classes/Categories H334 Resp. Sens. 1
2.1 Classification of the substance or mixture 5 mL Liquid Proteinase K GHS08 Signal Word DANGER Hazard Identification Hazard Classes/Categories H334 Resp. Sens. 1
2.2 Safety, Health and Environmental Regulations/Legislation specific for the Substance or Mixture According the implementation of GHS immediate packages only must be labelled with product identificator(s), GHS symbol(s), signal word, manufacturer name and phone number (OSHA's interpretation of HCS 2012). This labelling exemption is NOT valid for sensibilizing substances. 5 mL Liquid Proteinase K GHS08 Signal Word: DANGER H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. P261sh, P342+311 Avoid breathing dust/vapors.If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Label elements of the complete product GHS08 Signal Word: DANGER H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. P261sh, P342+311 Avoid breathing dust/vapors.If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
2.3 Other Hazards Possible Hazards from physicochemical Properties Information pertaining to particular Risks to Human and possible Symptoms Cause after impairments of health when ingested in small quantities. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Avoid inhalation of dust. Kit contains small amounts of enzymes, which may cause sensitization by direct and repeated contact. Information pertaining to particular Risks to the Environment PBT: not applicable vPvB: not applicable Possible endocrine disrupting effects
3.1 Substances or 3.2 Mixtures 5 mL Liquid Proteinase K Substance name: glycerole CAS No.: 56-81-5 Substance rating: No criteria for classification or naming of chemical is not required. Chemical Formula: C 3 H 8 O 3 Synonyms (de): 1,2,3-Propantriol REACH Reg. No.: 01-2119471987-18-xxxx EC No.: 200-289-5 Indice No.: n/a Concentration: 50 - <80 %acc. GHS: The criteria for classification are not fulfilled. Substance name: proteinase K, liquid CAS No.: 39450-01-6 Substance rating: H315, Skin Irrit. 2, H319, Eye Irrit. 2, H334, Resp. Sens. 1Chemical Formula: Enzyme Comm. No. 3.4.21.64, origin: tritirachium album Synonyms (de): Endopeptidase KEC No.: 254-457-8 Indice No.: 647-014-00-9 Concentration: 1 - <3 %acc. GHS: H334, Resp. Sens. 1
3.3 Remarks When not listed, mixtures are added with water [CAS No. 7732-18-5] to 100%.
4.1 Description of First-Aid Measures Place insured person out of danger zone to fresh air immediately. Ensure quiet, warmth, and provide resuscitation if necessary. If necessary contact medical advice. Take to a doctor, in a raised position if there are breathing difficulties.
4.1.1 After SKIN Contact Remove dust with wetted tissue. Remove contaminated clothing. Rinse the affected skin or mucous membrane thoroughly under running water.
4.1.2 After EYE Contact Rub dust with teardrops from eyes or: After contact with the eyes rinse thoroughly under running water with the eyelid wide open with eye washing bottle, eye douche or running water (protect intact eye).
4.1.3 After INHALATION of Vapors Administer a Dexamethasone spray as soon as possible. Ensure quiet, warmth, and provide resuscitation if necessary. In the event of respiratory distress ensure that the patient inhales oxygen. Secure the breathing, heart and circulatory function. After inhalation of dust fresh air should be inhaled.
4.1.4 After ORAL Intake After oral intake lots of water should be drunk after it has been ingested.
4.2 Most important Symptoms and Effects, both acute and delayed May cause allergy or asthma symptoms or breathing difficulties if inhaled. Chronic effects: Repeated contact, even in small amounts, can lead to sensitization.
4.3 Indication of any immediate Medical Attention and Special Treatment needed Inform patient respectively further measures and the possibility of long-term damages.
5.1 Extinguishable Media 5.1.1 Suitable extinguishing media Fire extinguishers appropriate to the fire classification, and, if applicable, a fire blanket must be available in a prominent location in the work area. All extinguishers like FOAM, WATER SPRAY, DRY POWDER, CARBON DIOXIDE can be used.
5.2 Special Hazards arising from the Substance or Mixture 5.3 Advice for Firefighters Product package burns like paper or plastic.
6.1 Personal Precautions, Protective Equipment and Emergency Procedure Avoid dusting. Do not breathe dust. Regular staff training is necessary, indicating hazards and precautions on the basis of operating instructions. Restrictions on activity must be observed.
6.2 Environmental Precautions PBT: not applicable vPvB: not applicable
6.3 Methods and Material for Containment and Cleaning up Remove remaining dust with a vacuum cleaner. If there is no vacuum cleaner, wet dust well and remove mechanical (Inhalation protection). And dispose in accordance to local regulations for the disposal of hazards. Clean any contaminated equipment and floors with plenty of water.
7.1 Precautions for Safe Handling Avoid dusting. Use only in well-ventilated working areas.
7.2 Conditions for Safe Storage, including any Incompatibilities The original product package allows a safe storage. Storage class (German chemical industry): see chapter 12.1 Storage class (VCI): 10 Water hazard class (DE): 1
7.2.1 Requirements for stock rooms and containers Keep original product packages tightly closed during handling and storage.
7.3 Specific End Use(s) Product for analytical use.
8.1 Control Parameters 5 mL Liquid Proteinase K Chemical: glycerole CAS No.: 56-81-5 DNEL: [inh] 56 mg/m³ PNEC (fresh water) : 0.885 mg/L Chemical: proteinase K, liquid CAS No.: 39450-01-6
8.2 Exposure Controls The highest level of cleanliness must be maintained at the workplace.
8.2.1 Respiratory Protection Use for open access of these substances for example a vapor/dust respirator, class A/AX. No additional recommendations.
8.2.2 Skin protection / Hand protection Yes, gloves (permeation time >30 min - level 2), consist of PVC.
8.2.3 Eye / Face Protection Yes, Splash Goggles.
8.2.4 Skin Protection Recommended to avoid contamination with these hazards.
8.2.5 Hygiene Measures Eating, drinking, smoking, taking snuff and storage of food in work areas and at outdoor workplaces is prohibited. Avoid contact with the skin, eyes and clothing. Rinse any clothing on which the substance has been spilled, and soak it in water. Wash hands thoroughly with soap and water when stopping work and before eating, and then apply protective skin cream.
8.3 Limitation and monitoring of environmental exposure Do not release product into environment.
9.1 Information on Basic Physical and Chemical Properties 5 mL Liquid Proteinase K a) State of aggregation: liquid b) Color: colorless c) Odor: odorless k) pH Value: 7-8 m) Soluble in Water: 0-100 % p) Specific Gravity: 1.1 g/cm³
10.1 Reactivity No further data available.
10.2 Chemical Stability no known instability.
10.3 Possibility of Hazardous Reactions No further data available.
10.4 Conditions to avoid No more required.
10.5 Incompatible Materials
10.6 Hazardous Decomposition Products In the original package all parts/all reagents are safety and separated stored. Decompositions are not observed during the expiration period under recommended conditions.
11.1 Information on Toxicological Effects Following information is valid for pure chemicals. Quantitative data on the toxicity of this product are not available. 5 mL Liquid Proteinase K Chemical: glycerole CAS No.: 56-81-5 TSCA Inventory: listed (1,2,3-Propanetriol) Exposure Routes: inhalation, skin and/or eye contact Target Organs: Eyes, skin, respiratory system, kidneys Symptoms: irritation eyes, skin, respiratory system; headache, nausea, vomiting; kidney injury LD50 orl rat : 12600 mg/kg Avoid inhalation of dust. Chemical: proteinase K, liquid CAS No.: 39450-01-6 TSCA Inventory: listed (CAS 102925-54-2) Acute Effects: Cause after impairments of health when ingested in small quantities. Chronic Effects: May cause sensitization by skin contact, also in repeated contact of small amounts. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Avoid inhalation of dust.
12.1 Toxicity Following information is valid for pure chemicals. 5 mL Liquid Proteinase K Chemical: glycerole CAS No.: 56-81-5 PNEC (fresh water) : 0.885 mg/L LC50 fish/96h : >5000 24h mg/L EC50 daphnia/48h : >10 24h g/L IC50 scenedesmus quadricauda/72h : IC5 7d >10 g/L EC10 pseudomonas putita/16h : EC5: >10 g/L Partition Coefficient (o/w) : -1,76 Chemical: proteinase K, liquid CAS No.: 39450-01-6
12.2 Persistence and Degradability not necessary
12.3 Bioaccumulative Potential not necessary
12.4 Mobility in Soil not necessary
12.5 Results of PBT and vPvB Assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
12.7 Other Adverse Effects no additional data available
Please observe local regulations for collection and disposal of hazardous waste and contact waste disposal company, where you will obtain information on laboratory waste disposal
14.1 - 14.4: No dangerous goods according the Transport regulations
14.5 Environmental Hazards none
14.6 Special Precautions for User not necessary
14.7 Carriage of bulk cargo by sea in accordance with IMO instruments Not applicable.
15.1 Safety, Health and Environmental Regulations/Legislation specific for the Substance or Mixture U.S. Federal Regulations OSHA "A Guide to The Globally Harmonized System of Classification and Labelling of Chemicals (GHS)" 29 CFR 1910.1200 Hazard communication. NIOSH Pocket Guide to Chemical Hazards NIOSH Workplace Safety & Health Topics TSCA Inventory U.S. State Regulations California Prop 65, Safe Drinking Water and Toxic Enforcement Act of 1986 Canada Canada CEPA 1999 - Domestic Substances List (DSL), List of Toxic Substances (Schedule 1)
15.2 Chemical Safety Assessment not necessary for these small amounts
16.1 Changes compared to the last version Between versions 2.2.3.3 and 2.2.2.2 following changes were applied: - 1 composition data corrected - 1 substance data corrected
16.2 List of Hazard and Precaution Phrases 16.2.1 List of relevant H Phrases H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. 16.2.2 List of relevant P Phrases P261sh Avoid breathing dust/vapors. P342+311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
16.3 Recommended Restriction on Use Only for Professional User. Look about employee restrictions for young people! Look about employee restrictions for pregnant women and nursing women! An individual package of this product or test kit has a moderate hazardous potential.
16.4 Sources of Key Data KÜHN, BIRETT, Leaflets on hazardous materials, 2021 Directive 1999/92/EG Minimum requirements to improve the safety and health protection of workers at risk from potentially explosive atmospheres SUVA .CH, limit values in the air at work 2009, revised on 01/2009 Regulation 790/2009/EU, adaptation of Regulation 1272/2008/EU to technical and scientific progress (1st ATP) Regulation 453/2010/EU, adaptation of the REACH regulation 1907/2006/EG TRGS 907, German technical rules for listing substances and causes of sensitization, updated November 2011 Regulation 487/2013/EU, adaptation of regulation 1272/2008/EG to technical and scientific progress (4th ATP) Regulation 1221/2015/EU, adaptation of regulation 1272/2008/EG to technical and scientific progress (7th ATP) Regulation 776/2017/EU, adaptation of regulation 1272/2008/EG to technical and scientific progress (10th ATP) Regulation 669/2018/EU, adaptation of Regulation 1272/2008/EC to technical and scientific progressText (11th ATP) Regulation 1480/2018/EU, adaptation of regulation 1272/2008/EG to technical and scientific progress (13th ATP) Regulation 521/2019/EU, adaptation of regulation 1272/2008/EG to technical and scientific progress (12th ATP) TRGS 900, German rules of technology on limit values in the air at work, as of 03/2019 Regulation 217/2020/EU, adaptation of Annex VI, Part 3, of Regulation 1272/2008/EC to technical and scientific progress (14th ATP) Regulation 878/2020/EU, adaptation of Annex II of the REACH regulation 1907/2006/EG Regulation 1182/2020/EU, adaptation of Annex VI, Part 3, of Regulation 1272/2008/EC to technical and scientific progress (15th ATP) Regulation 643/2021/EU, adaptation of Annex VI, Part 1, of Regulation 1272/2008/EC to technical and scientific progress (16th ATP) Regulation 849/2021/EU, adaptation of Annex VI, Part 3, of Regulation 1272/2008/EC to technical and scientific progress (17th ATP)
16.5 Further Information MACHEREY-NAGEL GmbH & Co. KG provides the information contained herein in good faith being up-to-date of own realizations at revision time. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgement in determining its appropriateness for a particular purpose. MACHEREY-NAGEL GmbH & Co. KG makes NO REPRESENTATIONS or WARRANTIES, either expressed or implied, including without limitation any warranties of merchantability, fitness for a particular purpose with respect to the information set forth herein or the product to which the information refers. Accordingly MACHEREY-NAGEL GmbH & Co. KG will not be responsible for damages resulting from use of or reliance upon this information. See terms and conditions at the end of our price lists for additional information.
16.6 Legend / Abbreviations acc: according ADR: Convention concerning the International Carriage of Dangerous Goods by Road Act: acute BAT: biological workplace tolerance value CAO: Cargo Aircraft Only Carc: carcinogen CAS: Chemical Abstracts Service CLP: Classification, Labelling and Packaging regulation CMR: carcinogen, mutagen, reproduction toxic Corr: corrosive COD: chemical oxigen demand CSCL: Chemical Substance Control Law (Jp) Dam: damage DNEL: Derived No-Effect Level (for workers) derm: dermal dog: dog EC10: Concentration causing a toxic effect in 10% of the test organisms EC: European Community EC-Nr: Substance number of the EC substance inventory EmS: Guide to accident management measures on ships EU: European Union fish: fish (not specified) GHS: Global Harmonized System of Classification and Labeling of Chemicals gpg: guinea pig ICAO: International Civil Aviation Organization ihl: inhaled IMDG: International Maritime Dangerous Goods Code intrav: intravenous ipt: intraperitonaeal ISHL: Industrial Safety and Health Law (Jp) LC50: letale concentration 50% LD50: letale dosis 50% leuciscus idus: fisch, ide, orfe MAK: maximum workplace concentration Met: Metall mus: mouse Muta: mutagen NIOSH: National Institute for Occupational Safety and Health (US) NRD: Non-rapidly degradable onchorhynchus mykiss: fish, rainbow trout orl: oral OSHA: Occupational Safety and Health Administration PAX: transport on passenger planes allowed PBT: persistent, bioaccumulating, toxic substance pH: pH value pimephales promelas: fish, fathead minnow PNEC: Predicted No Effected Concentration PROC 15: Process category 'for laboratory use' PRTR: Law for PRTR and Promotion of Chemical Management (Jp) PVC: polyvinyl chloride quail: bird, quail rat: rat rbt: rabbit RD: rapidly degradable RE: repeated REACh: Registration, Evaluation, Authorisation and Restriction of Chemicals REF: item number, reference number Reg.No.: rRegistration number Repr: harmful to reproduction Resp: respiratory scu: sub cutan RIP: REACH Implementations Projects SDS: safety data sheet Sens: sensitisation STEL: short term exposure limit STOT: Specific Target Organ Toxicity SVHC: Substance of Very High Concern t/a: tons per year TCCA: Toxic Chemicals Control Act (S. Korea) Tox: toxic TSCA: The Toxic Substances Control Act (US) TWA: time weighted average TRGS: technical regulations (DE) vPvB: very persistent, very bioaccumulating substance
16.7 Training Advice Regular safety training. Multiple safety training of staffs about danger and protection by using hazards in working area. Additionally training and introduction of staffs for using these products.
Bookmark
Daniel Féau processes personal data in order to optimise communication with our sales leads, our future clients and our established clients.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.